I noticed my rig was not functioning correctly anymore with RMS Trimode (v1.3.3.0).
I had applied the workaround mentioned in the setup guide for sysops to keep Windows 7 from changing the comm port upon any disconnect/power off of the rig. Well, Windows knows best and changed the serial port anyway so my rig could hear you but could not respond.
I have reset the com port for rig control, lets see how it goes today.